A possible crosstalk between cGMP pathway and Activin receptor-like kinase 7 (Alk7) in adipocytes
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چکیده
منابع مشابه
A novel crosstalk between Alk7 and cGMP signaling differentially regulates brown adipocyte function
OBJECTIVE Obesity is an enormous burden for patients and health systems world-wide. Brown adipose tissue dissipates energy in response to cold and has been shown to be metabolically active in human adults. The type I transforming growth factor β (TGFβ) receptor Activin receptor-like kinase 7 (Alk7) is highly expressed in adipose tissues and is down-regulated in obese patients. Here, we studied ...
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We previously identified a quantitative trait locus for adiposity, non-insulin-dependent diabetes 5 (Nidd5), on mouse chromosome 2. In the current study, we identified the actual genetic alteration at Nidd5 as a nonsense mutation of the Acvr1c gene encoding activin receptor-like kinase 7 (ALK7), one of the type I transforming growth factor-β receptors, which results in a COOH-terminal deletion ...
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ژورنال
عنوان ژورنال: BMC Pharmacology and Toxicology
سال: 2013
ISSN: 2050-6511
DOI: 10.1186/2050-6511-14-s1-p4